Peptosyn Oil: Important Usage & Safety Information
At Peptosyn, your safety and well-being are our top priorities. Please read all instructions and warnings carefully before using Peptosyn Oil. This information applies to both Peptosyn Oil and Kamboil (Previous Version)
This product makes no medical claims. Use is at your discretion.
Ingredients
At the heart of Peptosyn Oil are the powerful Peptides (Phyllomedusa Bicolour). These are synergistically blended with Lectin and the soothing essence of Rose Water. Complementing these core ingredients is our Proprietary Hydration Blend, a carefully selected complex of skin conditioners and humectants, including a plant-derived humectant, designed to ensure optimal absorption and leave your skin feeling wonderfully soft and supple.
How to Use Peptosyn Oil
Follow these steps for optimal application and to assess your skin’s unique response: Patch Test: Start by applying just one drop of Peptosyn Oil to the inside of your arm.

- Observe: Wait a full 24 hours. If no adverse reaction (such as hives or severe irritation) is observed, you may proceed with regular use. It is normal for the skin to become slightly red and sometimes itchy as the peptides enter the skin.
- Regular Application: If the patch test is clear, you can continue to use up to 5 drops of Peptosyn Oil per day.
- Application Areas: For better absorption and effectiveness, it is best to apply Peptosyn Oil to the inside of the arm. Peptosyn is flexible in application areas, but always avoid intimate areas, the face, and the ears. Also, avoid open wounds, irritated skin, and mucous membranes.
- Safety for Others: If you have constant contact with children or animals, it might be better to apply the oil on the side of the body on the trunk to minimise accidental exposure.
- Do not let children touch the application area.
- Do not let animals lick the area of application.
- Rinsing (Optional): You can gently rinse the applied area with warm water after 10 minutes of application if desired, without compromising absorption.
Important Warnings & Precautions
Please adhere to the following safety guidelines:
- Keep out of reach of children.
- For external use only. Not for internal use.
- If contact with the eyes occurs, rinse well with water immediately.
- Not suitable for children.
- Use within one month of opening.
- Keep refrigerated to maintain potency.
- Wash hands thoroughly after use.
Potential Side Effects
(IMPORTANT: Warnings and Contraindications for Kambo Peptides
Potential Systemic Effects:
Kambo secretions contain potent bioactive peptides that can have a significant physiological effect on the body.9 Even with topical application, these peptides can be absorbed through the skin and potentially lead to systemic effects.9 These effects may include changes in heart rate and blood pressure, and skin reactions.9 Severe adverse events, although rare, have been reported with Kambo use, but have not been observed with Peptosyn Oil 10
5.2 Contraindications:
The use of this topical oil containing Kambo peptides is contraindicated in certain populations and individuals with specific health conditions:
- Pregnancy and breastfeeding.13
- Children.16
- Severe and unstable cardiovascular conditions 13
- Hypotensive syndromes 18
- Psychosis, severe depression, and bipolar disorders 13
- Severe, unstable anxiety disorders 11
- Kidney or liver disease.13
- Epilepsy or seizure disorders 13
- Known allergy to frogs or amphibians.
. Safety in Specific Populations
8.1 Children:
This product is not safe for use on children due to potential sensitivity to Kambo peptides 10
8.2 Breastfeeding Individuals:
This product is not safe for use by breastfeeding individuals due to potential risks to the nursing infant.10
9. Important Considerations
This information is for informational purposes only and should not substitute professional medical advice. Consult a healthcare provider for any health concerns. Individual responses to Kambo peptides can vary. Even with guidance from a trained practitioner, adverse effects are possible. Follow any specific storage instructions provided with the product.
10. Disclaimer
This product is intended for use only as directed by a user or a trained Kambo practitioner, who has been trained by “KamboTree”. No regulatory authority has evaluated the statements in this leaflet. This product is not intended to diagnose, treat, cure, or prevent any disease. Use with realistic expectations and under the guidance of a professional.
Table 1: Bioactive Peptides in Kambo Secretion and Their Reported Effects
| Peptide | Reported Effects | Snippet References |
| Phyllocaerulein | Lowered blood pressure, nausea, vomiting | 17, 9, 17, 9, 17, 18, 9, 11, 11, 20, 9, 21, 17, 11, 22, 23, 12, 24, 23, 23, 21, 25, 26, 14, 27 |
| Phyllomedusin | Increased heart rate, heat flushing, red skin, hypotension, stimulates gut motility | 17, 9, 17, 9, 17, 18, 9, 11, 22, 11, 20, 13, 11, 24, 26, 9, 21, 17, 11, 22, 28, 24, 23, 23, 26, 21, 25, 22, 26, 15, 15 |
| Phyllokinin | Increased heart rate, heat flushing, red skin, hypotensive effects | 17, 9, 17, 9, 17, 18, 9, 11, 11, 20, 9, 21, 17, 11, 22, 24, 23, 23, 21, 25, 26, 29, 30, 31 |
| Sauvagine | Lowered blood pressure, nausea, vomiting, intense tachycardia | 9, 32, 33, 34, 13, 17, 2, 35, 24, 33, 21, 24, 36, 28, 23, 21, 26 |
| Dermorphins | Reduced pain, nausea, vomiting, euphoria | 10, 13, 2, 19, 37, 32, 18, 11, 34, 11, 38, 13, 20, 13, 2, 11, 24, 39, 21, 17, 24, 11, 11, 28, 10, 40, 41, 24, 23, 23, 42, 13, 21, 43, 39, 23, 44, 45, 46, 17, 22, 26, 47, 39, 48, 49, 47, 50, 51, 52, 47, 53, 54, 40, 53, 55, 56, 57, 55 |
| Deltorphins | Reduced pain, nausea, vomiting, euphoria, heat-flushing | 10, 13, 2, 19, 37, 32, 18, 11, 34, 11, 38, 13, 20, 13, 2, 11, 24, 39, 21, 17, 24, 11, 11, 28, 10, 40, 41, 24, 58, 23, 23, 42, 13, 21, 43, 39, 23, 44, 45, 46, 17, 22, 26, 47, 39, 48, 49, 47, 50, 51, 52, 47, 53, 54, 40, 53, 55, 56, 57, 55 |
Table 2: Potential Contraindications for Topical Kambo Oil
| Conditions; |
| Severe and unstable cardiovascular conditions |
| Hypotensive syndromes |
| Psychosis, severe depression, bipolar disorders, severe anxiety |
| Pregnancy |
| Breastfeeding |
| Epilepsy or seizure disorders |
| Liver or kidney dysfunction |
| Addison’s disease |
| History of stroke or brain haemorrhage |
| Aneurism |
| Blood clots |
| Low blood pressure |
Important Disclaimer: Use at Your Discretion
Important Disclaimer: Use at Your Discretion
Please note: Peptosyn Oil is offered for external use only. By purchasing and using this product, you acknowledge that you are doing so at your own risk.
We, including Lisa Silva & Kambo Tree, are not medical doctors and do not provide medical advice, diagnosis, or treatment. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been evaluated or approved by regulatory bodies such as the FDA (U.S. Food and Drug Administration) or equivalent health authorities in the EU or Portugal.
We strongly advise that you always consult with a qualified healthcare provider before using Peptosyn Oil, especially if you have pre-existing medical conditions, are pregnant or breastfeeding, or are taking any medications.
While Peptosyn has conducted all possible precautions and internal tests with no severe adverse reactions observed during our development process, individual responses to products can vary. Your health and safety are paramount.
